Description
A selective σ1 receptor agonist (Kis = 4.6 and 63 nM for σ1 and σ2, respectively); reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells at 10 µM; increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment at 10 mg/kg; reduces working and reference memory errors induced by a time delay and MK-801 in a radial arm maze in rats at 0.3 mg/kg; pre-administration into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer at 500 µM